Peng Wen-Wen, Song Wei-Wu, Huang Mao-Bo, Zeng Guang-Zhi, Tan Ning-Hua
Yao Xue Xue Bao. 2014 Dec;49(12):1689-93.
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
从黄皮树（芸香科）的根、茎和叶中分离出一种新的苯乙醇，即(2'R)-4-(2',3'-二羟基-3'-甲基丁氧基)-苯乙醇（1），以及其他11种已知的苯衍生物（2-12）。化合物3和4是新的天然产物，化合物5-8、10-12首次从黄皮树中分离得到。通过质谱、一维和二维核磁共振光谱分析（包括HSQC、COSY和HMBC实验）阐明了它们的结构。对1进行了针对A549、HeLa和BGC-823癌细胞系的细胞毒性测试，以及针对白色念珠菌和金黄色葡萄球菌的抗菌活性测试。结果表明，1没有表现出细胞毒性和抗菌活性。
