哮喘：超越皮质类固醇治疗。
Asthma: beyond corticosteroid treatment.
机构信息
Department of Pharmacology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Arch Med Sci. 2013 Jun 20;9(3):521-6. doi: 10.5114/aoms.2013.33179. Epub 2013 Feb 10.
Abstract
Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. It is an inflammatory disorder characterized by bronchoconstriction and airway hyperresponsiveness, followed by inflammatory manifestations in the respiratory system. The prevalence of asthma is rising and there is a clinical need to develop more effective treatments. While corticosteroids (glucocorticosteroids) remain the mainstay of asthma therapy, they have limitations because of their potentially severe side-effects and the presence of corticosteroid resistance in some patients. This review discusses current strategies in the treatment of asthma and considers new therapeutic regimens of asthma in the drug development pipeline.
摘要
哮喘是世界上最常见的慢性疾病之一，影响着超过 3 亿人。它是一种以支气管收缩和气道高反应性为特征的炎症性疾病，随后在呼吸系统出现炎症表现。哮喘的患病率正在上升，因此临床需要开发更有效的治疗方法。虽然皮质类固醇（糖皮质激素）仍然是哮喘治疗的主要药物，但由于其潜在的严重副作用以及一些患者存在皮质激素抵抗，它们存在局限性。本文讨论了目前哮喘治疗的策略，并考虑了药物开发管道中哮喘的新治疗方案。
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