Liakat Sabbir, Bors Kevin A, Huang Tzu-Yung, Michel Anna P M, Zanghi Eric, Gmachl Claire F
Department of Electrical Engineering, Princeton University, Princeton, NJ 08540, USA.
Biomed Opt Express. 2013 Jun 11;4(7):1083-90. doi: 10.1364/BOE.4.001083. Print 2013 Jul 1.
Mid-infrared transmission spectroscopy using broadband mid-infrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared.
使用宽带中红外或量子级联激光源的中红外透射光谱法用于预测含有生理相关量葡萄糖（50 - 400mg/dL）的水溶液和血清溶液中的葡萄糖浓度。我们采用偏最小二乘回归，利用所采集光谱的一个子集生成校准模型，并从新光谱预测浓度。无论背景溶剂如何，对于低至30mg/dL的浓度，在克拉克误差网格方面都进行了临床准确测量。这些结果是朝着开发中红外无创体内葡萄糖传感器的工作迈出的重要且令人鼓舞的一步。
