Christison G B, MacKenzie H A
Critical Sciences Ltd., London, UK.
Med Biol Eng Comput. 1993 May;31(3):284-90. doi: 10.1007/BF02458048.
A glucose concentration analysis of human whole blood samples has been accomplished using pulsed laser photoacoustic spectroscopy (LPAS). Using a CO2 laser operating with microJ pulse energies, the technique has shown the required discrimination and sensitivity to determine glucose concentrations within the physiological range (18-450 mg dl-1) in whole blood samples. The sensitivity achieved with this system is comparable to that of the existing commercial enzyme-based diagnostic systems presently used in hospital clinical chemistry environments. The technique is compared with other optical methods that have recently been used for glucose determination, and its applicability for use in the development of an in vivo monitor is discussed.
已使用脉冲激光光声光谱法（LPAS）完成了对人类全血样本的葡萄糖浓度分析。使用具有微焦脉冲能量的二氧化碳激光器，该技术已显示出在全血样本中测定生理范围内（18 - 450毫克/分升）葡萄糖浓度所需的分辨能力和灵敏度。该系统实现的灵敏度与目前医院临床化学环境中使用的现有基于酶的商业诊断系统相当。将该技术与最近用于葡萄糖测定的其他光学方法进行了比较，并讨论了其在体内监测器开发中的适用性。
