Department of Obstetrics and Gynaecology, Mater Dei Hospital, Msida MSD 2090, Malta.
Best Pract Res Clin Obstet Gynaecol. 2013 Oct;27(5):727-40. doi: 10.1016/j.bpobgyn.2013.06.004. Epub 2013 Jul 10.
Collagen atrophy is a major factor in skin ageing. A strong correlation exists between skin collagen loss and oestrogen deficiency caused by the menopause. Skin ageing is associated with a progressive increase in extensibility and a reduction in elasticity. With increasing age, the skin also becomes more fragile and susceptible to trauma, leading to more lacerations and bruising. Furthermore, wound healing is impaired in older women. Oestrogen use after the menopause increases collagen content, dermal thickness and elasticity, and it decreases the likelihood of senile dry skin. Large-scale clinical trials are necessary to help make informed recommendations about postmenopausal oestrogen use and its role in preventing skin ageing.
胶原萎缩是皮肤老化的主要因素。皮肤胶原丧失与绝经引起的雌激素缺乏之间存在很强的相关性。皮肤老化与伸展性的逐渐增加和弹性的降低有关。随着年龄的增长，皮肤也变得更加脆弱，容易受到创伤，导致更多的撕裂和瘀伤。此外，老年女性的伤口愈合能力也受到影响。绝经后使用雌激素可增加胶原蛋白含量、真皮厚度和弹性，并降低老年干性皮肤的可能性。有必要进行大规模临床试验，以便就绝经后使用雌激素及其在预防皮肤老化方面的作用提出明智的建议。
