Wosicka-Frąckowiak Hanna, Poniedziałek Kornelia, Woźny Stanisław, Kuprianowicz Mateusz, Nyga Martyna, Jadach Barbara, Milanowski Bartłomiej
GENERICA Pharmaceutical Lab, Regionalne Centrum Zdrowia Sp. z o.o., ul. Na Kępie 3, 64-360 Zbąszyń, Poland.
Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, ul. Rokietnicka 3, 60-806 Poznan, Poland.
Polymers (Basel). 2024 Sep 22;16(18):2668. doi: 10.3390/polym16182668.
Biomaterials have been the subject of extensive research, and their applications in medicine and pharmacy are expanding rapidly. Collagen and its derivatives stand out as valuable biomaterials due to their high biocompatibility, biodegradability, and lack of toxicity and immunogenicity. This review comprehensively examines collagen from various sources, its extraction and processing methods, and its structural and functional properties. Preserving the native state of collagen is crucial for maintaining its beneficial characteristics. The challenges associated with chemically modifying collagen to tailor its properties for specific clinical needs are also addressed. The review discusses various collagen-based biomaterials, including solutions, hydrogels, powders, sponges, scaffolds, and thin films. These materials have broad applications in regenerative medicine, tissue engineering, drug delivery, and wound healing. Additionally, the review highlights current research trends related to collagen and its derivatives. These trends may significantly influence future developments, such as using collagen-based bioinks for 3D bioprinting or exploring new collagen nanoparticle preparation methods and drug delivery systems.
生物材料一直是广泛研究的主题，并且它们在医学和药学中的应用正在迅速扩展。胶原蛋白及其衍生物因其高生物相容性、可生物降解性以及缺乏毒性和免疫原性而成为有价值的生物材料。本综述全面研究了来自各种来源的胶原蛋白、其提取和加工方法以及其结构和功能特性。保持胶原蛋白的天然状态对于维持其有益特性至关重要。还讨论了为满足特定临床需求而对胶原蛋白进行化学改性以调整其性能所面临的挑战。该综述讨论了各种基于胶原蛋白的生物材料，包括溶液、水凝胶、粉末、海绵、支架和薄膜。这些材料在再生医学、组织工程、药物递送和伤口愈合方面有广泛应用。此外，该综述强调了与胶原蛋白及其衍生物相关的当前研究趋势。这些趋势可能会显著影响未来的发展，例如使用基于胶原蛋白的生物墨水进行3D生物打印或探索新的胶原蛋白纳米颗粒制备方法和药物递送系统。
