Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, UK.
Neurosci Biobehav Rev. 2013 Sep;37(8):1724-37. doi: 10.1016/j.neubiorev.2013.07.001. Epub 2013 Jul 9.
Emotion, memories and behaviour emerge from the coordinated activities of regions connected by the limbic system. Here, we propose an update of the limbic model based on the seminal work of Papez, Yakovlev and MacLean. In the revised model we identify three distinct but partially overlapping networks: (i) the Hippocampal-diencephalic and parahippocampal-retrosplenial network dedicated to memory and spatial orientation; (ii) The temporo-amygdala-orbitofrontal network for the integration of visceral sensation and emotion with semantic memory and behaviour; (iii) the default-mode network involved in autobiographical memories and introspective self-directed thinking. The three networks share cortical nodes that are emerging as principal hubs in connectomic analysis. This revised network model of the limbic system reconciles recent functional imaging findings with anatomical accounts of clinical disorders commonly associated with limbic pathology.
情绪、记忆和行为源自由边缘系统连接的区域的协调活动。在这里，我们基于 Papez、Yakovlev 和 MacLean 的开创性工作，提出了对边缘系统模型的更新。在修正后的模型中，我们确定了三个不同但部分重叠的网络：（i）海马-间脑和海马旁回-胼胝体后部网络，专门用于记忆和空间定位；（ii） 颞叶杏仁核-眶额皮质网络，用于将内脏感觉和情绪与语义记忆和行为整合；（iii） 默认模式网络，涉及自传体记忆和内省自我导向思维。这三个网络共享皮质节点，这些节点正在成为连接组分析中的主要枢纽。这个修正后的边缘系统网络模型将最近的功能成像发现与常见于边缘系统病理学的临床障碍的解剖学描述统一起来。
