Inagaki H, Sakamoto J, Nakazato H, Bishop A E, Yura J
1st Department of Surgery, Nagoya City University, Japan.
J Surg Oncol. 1990 Aug;44(4):208-13. doi: 10.1002/jso.2930440404.
An immunohistochemical analysis of the expression of Lewis(a), Lewis(b), and sialated Lewis(a) blood group antigens was performed on specimens of human non-involved stomach (n = 91), early gastric cancers (n = 41), and advanced gastric cancers (n = 50). In non-involved stomach, Lewis(a) and Lewis(b) were detected mainly in surface epithelium, although sialated Lewis(a) was scarcely expressed. These blood group-related antigens were rarely observed in deep glands. In gastric cancers, Lewis(a) showed a tendency to be expressed in well or moderately differentiated carcinomas, and this was observed to be more marked in advanced tumors. There was no obvious difference in positive ratios of Lewis(b) between degrees of differentiation of the cancers. Sialated Lewis(a) was not detected in early cancers, and its frequent expression in well- or moderately differentiated, advanced carcinomas suggested an association with both cancer differentiation and progression. These results indicate that knowledge of the expression of blood group antigens may help interpret the antigenic alterations occurring in the course of carcinogenesis, differentiation, and progression of gastric cancers.
对91例未受累的人胃标本、41例早期胃癌标本和50例进展期胃癌标本进行了Lewis(a)、Lewis(b)和唾液酸化Lewis(a)血型抗原表达的免疫组化分析。在未受累的胃中，Lewis(a)和Lewis(b)主要在表面上皮中检测到，而唾液酸化Lewis(a)几乎不表达。这些血型相关抗原在深部腺体中很少观察到。在胃癌中，Lewis(a)倾向于在高分化或中分化癌中表达，在进展期肿瘤中这种表达更为明显。癌症不同分化程度之间Lewis(b)的阳性率没有明显差异。早期癌症中未检测到唾液酸化Lewis(a)，其在高分化或中分化的进展期癌中的频繁表达提示与癌症分化和进展均有关联。这些结果表明，了解血型抗原的表达可能有助于解释胃癌发生、分化和进展过程中发生的抗原改变。
