Design and evaluation of a miniature probe integrating diffuse optical tomography and electroencephalographic source localization.

We present a dual-modality three-dimensional imaging approach that integrates diffuse optical tomography (DOT) and electroencephalographic source localization (ESL). This dual-modal DOT/ESL approach is evaluated using solid tissue-like phantoms where targets having both optical and electrical contrasts relative to the background phantom are included. The results obtained from extensive phantom experiments show that this dual-modal approach is suitable for imaging seizure focus in the study of epilepsy.