GP's Office, Novska, Croatia.
Med Sci Monit. 2013 Jul 12;19:571-8. doi: 10.12659/MSM.889343.
This study compared the association between the 3 definitions of metabolic syndrome (MetS) suggested by the World Health Organization (WHO), National Cholesterol Education Programme (NCEP ATP III), and International Diabetes Federation (IDF), and the risk of cardiovascular diseases (CVD) and shows the prevalence and characteristics of persons with MetS in continental vs. coastal regions and rural vs. urban residence in Croatia.
MATERIAL/METHODS: A prospective multicenter study was conducted on 3245 participants≥40 years, who visited general practices from May to July 2008 for any reason. This was a cross-sectional study of the Cardiovascular Risk and Intervention Study in Croatia-family medicine project (ISRCTN31857696).
All analyzed MetS definitions showed an association with CVD, but the strongest was shown by NCEP ATP III; coronary disease OR 2.48 (95% CI 1.80-3.82), cerebrovascular disease OR 2.14 (1.19-3.86), and peripheral artery disease OR 1.55 (1.04-2.32), especially for age and male sex. According to the NCEP ATP III (IDF), the prevalence was 38.7% (45.9%) [15.9% (18.6%) in men, and 22.7% (27.3%) in women, and 28.4% (33.9%) in the continental region, 10.2% (10.9%) in the coastal region, 26.2% (31.5%) in urban areas, and 12.4% (14.4%) in rural areas. Older age, male sex, and residence in the continental area were positively associated with MetS diagnosis according to NCEP ATP III, and current smoking and Mediterranean diet adherence have protective effects.
The NCEP ATP III definition seems to provide the strongest association with CVD and should therefore be preferred for use in this population.
本研究比较了世界卫生组织（WHO）、美国国家胆固醇教育计划（NCEP ATP III）和国际糖尿病联合会（IDF）提出的三种代谢综合征（MetS）定义与心血管疾病（CVD）风险的关联，并展示了克罗地亚大陆与沿海地区以及农村与城市居民中 MetS 患者的患病率和特征。
这是一项前瞻性多中心研究，共纳入 3245 名年龄≥40 岁的参与者，他们于 2008 年 5 月至 7 月间因任何原因就诊于普通诊所。这是克罗地亚心血管风险与干预研究-家庭医学项目（ISRCTN31857696）的横断面研究。
所有分析的 MetS 定义均与 CVD 相关，但 NCEP ATP III 定义的关联最强；冠心病 OR 2.48（95%CI 1.80-3.82）、脑血管疾病 OR 2.14（1.19-3.86）和外周动脉疾病 OR 1.55（1.04-2.32），特别是对于年龄和男性性别。根据 NCEP ATP III（IDF）定义，患病率为 38.7%（45.9%）[男性 15.9%（18.6%），女性 22.7%（27.3%），大陆地区 28.4%（33.9%），沿海地区 10.2%（10.9%），城市地区 26.2%（31.5%），农村地区 12.4%（14.4%）]。NCEP ATP III 定义中，年龄较大、男性和居住在大陆地区与 MetS 诊断呈正相关，而当前吸烟和地中海饮食依从性具有保护作用。
NCEP ATP III 定义似乎与 CVD 关联最强，因此应优先用于该人群。
