Deka R, Durakovic Z, Niu W, Zhang G, Karns R, Smolej-Narancic N, Missoni S, Caric D, Caric T, Rudan D, Salzer B, Chakraborty R, Rudan P
Department of Environmental Health, Center for Genome Information, University of Cincinnati, Cincinnati, Ohio 45267-0056, USA.
Ann Hum Biol. 2012 Jan;39(1):46-53. doi: 10.3109/03014460.2011.637512. Epub 2011 Dec 12.
Metabolic syndrome, a constellation of risk factors associated with cardiovascular disease and Type 2 diabetes, has reached epidemic proportions worldwide. Epidemiological studies in transitional societies will provide insight into the underlying factors that interact in its manifestation.
To estimate the prevalence of metabolic syndrome, provide a comparative analysis of two metabolic syndrome definitions and assess clustering and association of metabolic traits and cardiovascular diseases in an Adriatic island population.
In a cross-sectional study, data on four anthropometric, blood pressure and 11 biochemical traits were obtained from 1430 adults from the island of Hvar.
Prevalence of metabolic syndrome was 25% and 38.5% based on Adult Treatment Panel III and International Diabetes Federation definitions, respectively. Rates of abdominal obesity, elevated blood glucose and hypertension were high. Among the traits not included in the definitions, levels of LDL, total cholesterol and fibrinogen were markedly elevated. The majority of the phenotypes were significantly associated with the syndrome, the strongest being waist circumference.
The Croatian islanders are characterized by a high prevalence of metabolic abnormalities. Central obesity is the strongest contributor of the syndrome. With a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases.
代谢综合征是一组与心血管疾病和2型糖尿病相关的危险因素，在全球已达到流行程度。对转型社会的流行病学研究将有助于深入了解其表现中相互作用的潜在因素。
估计代谢综合征的患病率，对两种代谢综合征定义进行比较分析，并评估亚得里亚海岛屿人群中代谢特征与心血管疾病的聚集性和关联性。
在一项横断面研究中，从赫瓦尔岛的1430名成年人中获取了四项人体测量、血压和11项生化特征的数据。
根据成人治疗小组第三次报告（Adult Treatment Panel III，ATP III）和国际糖尿病联盟（International Diabetes Federation，IDF）的定义，代谢综合征的患病率分别为25%和38.5%。腹部肥胖、血糖升高和高血压的发生率很高。在定义中未包括的特征中，低密度脂蛋白、总胆固醇和纤维蛋白原水平明显升高。大多数表型与该综合征显著相关，最强的是腰围。
克罗地亚岛民的特点是代谢异常患病率高。中心性肥胖是该综合征的最强促成因素。由于血脂异常和促炎因子的高患病率，该人群面临心血管疾病的重大风险。
