Institute of Neurosciences, Fourth Military Medical University, Xi'an 710032, China.
Neurosci Bull. 2013 Aug;29(4):501-8. doi: 10.1007/s12264-013-1354-7. Epub 2013 Jul 13.
Expansion of the secondary injury following primary spinal cord injury is a major pathological event that increases destruction in the spinal cord, so measures to reduce secondary injury are needed. Our previous study demonstrated that, at the front of the expanding secondary injury in the spinal cord, there is an ischemic area in which many neurons can still be rescued. Therefore, enhancement of blood circulation in the cord may be helpful, and indeed, we found that a traditional Chinese medicine, shu-xue-tong, efficiently reduces the secondary injury. The aim of the present study was to investigate the effect of reducing fibrinogen with Batroxobin, a drug widely used clinically for ischemia, in rats with spinal cord contusion. We found that both 2 and 4 Batroxobin units (BU)/kg efficiently decreased the plasma fibrinogen, and 2 BU/kg significantly increased spinal blood flow, enhanced neuronal survival, mitigated astrocyte and microglia activation, and improved locomotor recovery. However, 4 BU/kg had no effect on the secondary spinal cord injury. These data suggest that Batroxobin has multiple beneficial effects on spinal cord injury, indicating a potential clinical application.
原发性脊髓损伤后二次损伤的扩展是导致脊髓破坏加重的主要病理事件，因此需要采取措施减少二次损伤。我们之前的研究表明，在脊髓二次损伤扩展的前沿，存在一个缺血区域，其中许多神经元仍可被挽救。因此，增强脊髓的血液循环可能会有帮助，事实上，我们发现一种中药，疏血通，能有效减轻二次损伤。本研究的目的是探讨用巴曲酶降低纤维蛋白原对脊髓挫伤大鼠的影响。巴曲酶是一种广泛用于缺血治疗的药物。我们发现，2 个和 4 个巴曲酶单位（BU）/kg 能有效降低血浆纤维蛋白原，2 BU/kg 能显著增加脊髓血流量，增强神经元存活，减轻星形胶质细胞和小胶质细胞的激活，并改善运动功能恢复。然而，4 BU/kg 对脊髓的继发性损伤没有影响。这些数据表明，巴曲酶对脊髓损伤有多种有益作用，表明其具有潜在的临床应用价值。
