肾脏转运的数学建模。
Mathematical modeling of kidney transport.
机构信息
Department of Mathematics, Duke University, Durham, NC, USA.
出版信息
Wiley Interdiscip Rev Syst Biol Med. 2013 Sep-Oct;5(5):557-73. doi: 10.1002/wsbm.1232. Epub 2013 Jul 12.
Abstract
In addition to metabolic waste and toxin excretion, the kidney also plays an indispensable role in regulating the balance of water, electrolytes, nitrogen, and acid-base. In this review, we describe representative mathematical models that have been developed to better understand kidney physiology and pathophysiology, including the regulation of glomerular filtration, the regulation of renal blood flow by means of the tubuloglomerular feedback mechanisms and of the myogenic mechanism, the urine concentrating mechanism, epithelial transport, and regulation of renal oxygen transport. We discuss the extent to which these modeling efforts have expanded our understanding of renal function in both health and disease.
摘要
除了代谢废物和毒素的排泄，肾脏在调节水、电解质、氮和酸碱平衡方面也起着不可或缺的作用。在这篇综述中，我们描述了一些有代表性的数学模型，这些模型的建立有助于更好地理解肾脏的生理和病理生理学，包括肾小球滤过的调节、通过管球反馈机制和肌源性机制对肾血流量的调节、尿液浓缩机制、上皮细胞转运以及肾脏氧运输的调节。我们讨论了这些建模工作在多大程度上扩展了我们对健康和疾病状态下肾脏功能的理解。
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