Jameel Tahir, Mehmood Khalid, Mujtaba Ghulam, Choudhry Nakhshab, Afzal Naeema, Paul Rubina Faisal
lttefaq Hospital (Trust), Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2012 Jan-Mar;24(1):3-6.
Dengue Fever is the most common arboviral disease in the world, and presents cyclically in tropical and subtropical regions of the world. The four serotypes of dengue virus, 1, 2, 3, and 4, form an antigenic subgroup of the flaviviruses (Group B arboviruses). Transmission to humans of any of these serotypes initiates a spectrum of host responses, from in apparent to severe and sometimes lethal infections. Complete Blood count (CBC) is an important part of the diagnostic workup of patients. Comparison of various finding in CBC including peripheral smear can help the physician in better management of the patient.
This cross sectional study was carried out on a series of suspected patients of Dengue viral infection reporting in Ittefaq Hospital (Trust). All were investigated for serological markers of acute infection.
Out of 341 acute cases 166 (48.7%) were confirmed by IgM against Dengue virus. IgG anti-dengue was used on 200 suspected re-infected patients. Seventy-one (39.5%) were positive and 118 (59%) were negative. Among 245 confirmed dengue fever patients 43 (17.6%) were considered having dengue hemorrhagic fever on the basis of lab and clinical findings. Raised haematocrit, Leukopenia with relative Lymphocytosis and presence atypical lymphocytes along with plasmacytoid cells was consistent finding at presentation in both the patterns of disease, i.e., Dengue Haemorrhagic fever (DHF) and Dengue fever (DF).
Changes in relative percentage of cells appear with improvement in the symptoms and recovery from the disease. These findings indicate that in the course of the disease, there are major shifts within cellular component of blood.
登革热是世界上最常见的虫媒病毒病，在世界热带和亚热带地区呈周期性流行。登革病毒的四种血清型，即1型、2型、3型和4型，构成了黄病毒属（B组虫媒病毒）的一个抗原亚组。这些血清型中的任何一种传播给人类都会引发一系列宿主反应，从隐性感染到严重感染，有时甚至是致命感染。全血细胞计数（CBC）是患者诊断检查的重要组成部分。比较CBC中的各种检查结果，包括外周血涂片，有助于医生更好地管理患者。
本横断面研究针对伊特法克医院（信托医院）报告的一系列疑似登革病毒感染患者进行。所有患者均接受了急性感染血清学标志物的检测。
在341例急性病例中，166例（48.7%）通过抗登革病毒IgM确诊。对200例疑似再次感染患者检测了抗登革病毒IgG。71例（39.5%）呈阳性，118例（59%）呈阴性。在245例确诊的登革热患者中，根据实验室和临床检查结果，43例（17.6%）被认为患有登革出血热。血细胞比容升高、白细胞减少伴相对淋巴细胞增多以及出现非典型淋巴细胞和浆细胞样细胞是两种疾病类型，即登革出血热（DHF）和登革热（DF）发病时的一致表现。
随着症状改善和疾病康复，细胞相对百分比会发生变化。这些发现表明，在疾病过程中，血液的细胞成分会发生重大变化。
