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Enhanced innate immunity as explanation for reduced Mycobacterium tuberculosis infection in Bacillus Calmette-Guérin-immunized children.

作者信息

Eisenhut Michael

出版信息

Am J Respir Crit Care Med. 2013 Jul 15;188(2):257-8. doi: 10.1164/rccm.201301-0060LE.

DOI:10.1164/rccm.201301-0060LE
PMID:23855702
Abstract
摘要

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Enhanced innate immunity as explanation for reduced Mycobacterium tuberculosis infection in Bacillus Calmette-Guérin-immunized children.卡介苗免疫儿童结核分枝杆菌感染减少的原因:先天免疫增强
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Reduction of Mycobacterium tuberculosis infection in Bacillus Calmette Guerin immunized people is due to training of innate immunity.卡介苗免疫人群中结核分枝杆菌感染的减少归因于天然免疫的训练。
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Immunometabolic Pathways in BCG-Induced Trained Immunity.卡介苗诱导的训练性免疫中的免疫代谢途径
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Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model.在高度易感动物模型中,表达结核分枝杆菌30 kDa主要分泌蛋白的重组卡介苗(BCG)疫苗比传统卡介苗疫苗诱导出更强的抗结核保护性免疫。
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引用本文的文献

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Is Systemic Dissemination of BCG Following Neonatal Vaccination Required for Protection Against Mycobacterium tuberculosis?新生儿接种卡介苗后,卡介苗的全身播散对于预防结核分枝杆菌感染是否必要?
J Infect Dis. 2025 Jul 11;231(6):e1019-e1021. doi: 10.1093/infdis/jiaf051.
2
The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits.成功的标志:疫苗诱导的皮肤瘢痕形成在卡介苗和天花疫苗相关临床获益中的作用。
Semin Immunopathol. 2024 Aug 26;46(5):13. doi: 10.1007/s00281-024-01022-9.
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BCG: a vaccine with multiple faces.
BCG:一种具有多种面貌的疫苗。
Hum Vaccin Immunother. 2020 Aug 2;16(8):1841-1850. doi: 10.1080/21645515.2019.1706930. Epub 2020 Jan 29.
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Stimulation of Nucleotide Oligomerization Domain and Toll-Like Receptors 2 to Enhance the Effect of Bacillus Calmette Guerin Immunization for Prevention of Mycobacterium Tuberculosis Infection: Protocol for a Series of Preclinical Randomized Controlled Trials.刺激核苷酸寡聚化结构域和Toll样受体2以增强卡介苗免疫预防结核分枝杆菌感染的效果:一系列临床前随机对照试验方案
JMIR Res Protoc. 2019 Jun 8;8(6):e13045. doi: 10.2196/13045.