胎儿发育过程中的细胞外钙敏感受体（CaSR）。
The extracellular calcium-sensing receptor, CaSR, in fetal development.
机构信息
School of Biosciences, Cardiff University, Cardiff, UK.
出版信息
Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):443-53. doi: 10.1016/j.beem.2013.02.010. Epub 2013 Mar 26.
Abstract
In fetal mammals, serum levels of both total and ionized calcium significantly exceed those in the adult. This relative fetal hypercalcemia is crucial for skeletal development and is maintained irrespectively of maternal serum calcium levels. Elegant studies by Kovacs and Kronenberg have previously addressed the role of the CaSR in creating and maintaining this relative fetal hypercalcemia, through the regulation of parathyroid hormone-related peptide secretion. More recently we have shown that the CaSR is widely distributed throughout the developing fetus, where the receptor plays major, unexpected roles in ensuring growth and maturation of several organs. In this article, we present evidence for a role of the CaSR in the control of skeletal development, and how fetal hypercalcemia, acting through the CaSR, regulates lung development.
摘要
在胎生哺乳动物中，血清总钙和离子钙的水平都显著高于成人。这种相对的胎儿高钙血症对于骨骼发育至关重要，并且独立于母体血清钙水平维持。Kovacs 和 Kronenberg 的精彩研究以前已经通过调节甲状旁腺激素相关肽的分泌来解决钙敏感受体在产生和维持这种相对胎儿高钙血症中的作用。最近，我们已经表明，钙敏感受体广泛分布于发育中的胎儿中，在那里，该受体在确保几个器官的生长和成熟方面发挥主要的、意想不到的作用。在这篇文章中，我们提出了钙敏感受体在骨骼发育控制中的作用的证据，以及胎儿高钙血症如何通过钙敏感受体调节肺发育。
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