Unité de Bioénergétique et Ingénierie des Protéines, Institut de Microbiologie de la Méditerranée, CNRS-Aix-Marseille Université, 31 chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France.
FEBS Lett. 2013 Sep 2;587(17):2767-71. doi: 10.1016/j.febslet.2013.07.014. Epub 2013 Jul 13.
This article sketches the road from the establishment of the principles of enzyme kinetics, at the beginning of the 20th century, to the discovery of regulatory mechanisms and the models to explain them, from the middle of the century onwards. A long gap in time separates the two periods, in which technological advances were made that allowed the discovery of feedback inhibition and cooperativity. In particular, these discoveries and the theory needed to explain them could not have been made without knowledge of the major metabolic pathways and the enzymes and metabolites involved in them.
本文概述了从 20 世纪初确立酶动力学原理，到发现调节机制及其解释模型（从中期开始）的发展历程。这两个时期之间存在很长的时间间隔，在此期间，技术取得了进步，使得发现反馈抑制和协同作用成为可能。特别是，如果没有对主要代谢途径以及其中涉及的酶和代谢物的了解，这些发现及其解释理论是不可能取得的。
