Bălăiţă C, Christodorescu D, Năstase R, Iscrulescu C, Dimian G
Institute of Neurology and Psychiatry, Bucharest, Romania.
Rom J Neurol Psychiatry. 1990 Apr-Jun;28(2):127-34.
The paper aims at finding whether the serum creatine-kinase activity may be considered as a biological state or a trait-marker in major depression. The study performed in 76 patients (males and females) led to the conclusion that significant increases of the enzymic activity as compared with controls are present in depressive and not in euthymic patients. The same significant increase was found when comparing the depressive and euthymic patients (but not in the group of monopolar depressive females). There were no significant differences between the monopolar and the bipolar form of the disease. The data reported by the authors show that serum creatine-kinase is not a trait-marker in primary affective illness, but it may be taken for a state-marker in this disease. However, the enzyme is not a biochemical discriminant for the type of depression.
本文旨在探究血清肌酸激酶活性是否可被视为重度抑郁症的一种生物学状态或特质标志物。对76名患者（男女皆有）进行的研究得出结论：与对照组相比，抑郁患者的酶活性显著升高，而心境正常的患者则不然。在比较抑郁患者和心境正常的患者时也发现了同样显著的升高（但在单相抑郁女性组中未发现）。该疾病的单相和双相形式之间没有显著差异。作者报告的数据表明，血清肌酸激酶不是原发性情感障碍的特质标志物，但可能是该疾病的状态标志物。然而，该酶并非抑郁症类型的生化判别指标。
