Năstase R, Bălăiţă C, Iscrulescu C, Petrea A
Institute of Neurology and Psychiatry, Bucharest, Romania.
Rom J Neurol Psychiatry. 1993 Apr-Jun;31(2):97-103.
The study aims to observe whether subjects with a primary affective disease and manic attacks show modifications of serum concentration of creatine-kinase conferring it the role of a biologic marker. Serum concentration of creatine-kinase was determined for 122 men with mono- and bipolar affective disease during the different stages as well as for schizophrenic men with different clinical forms excepting the affective form. The control group included 60 men. Data indicated that enzyme concentration can constitute a biological marker for a primary affective disease also showing the differences between the different stages of the disease (mania, hypomania, depression and the symptom-free intervals).
该研究旨在观察患有原发性情感疾病且有躁狂发作的受试者血清肌酸激酶浓度是否发生改变，从而赋予其生物标志物的作用。对122名患有单相和双相情感疾病的男性患者在不同阶段测定了血清肌酸激酶浓度，同时也对患有不同临床类型（除情感型外）的精神分裂症男性患者进行了测定。对照组包括60名男性。数据表明，酶浓度可构成原发性情感疾病的生物标志物，同时也显示出该疾病不同阶段（躁狂、轻躁狂、抑郁和无症状期）之间的差异。
