Petersen J P, Schellhammer P F, el-Mahdi A M
Department of Radiation Oncology and Biophysics, Eastern Virginia Medical School, Norfolk.
Urology. 1990 Aug;36(2):103-6. doi: 10.1016/0090-4295(90)80206-3.
In some retrospective studies perioperative transfusions during oncologic surgery have been shown to decrease the time interval between surgery and local and/or distant recurrence of cancer. This study examines the disease-related effect, if any, of perioperative blood transfusions among 108 patients with localized carcinoma of the prostate treated by radioactive iodine-125 seed implantation of the prostate and lymphadenectomy. When all subjects were analyzed, there was no statistical difference of local and distant failure between the transfused and nontransfused groups. Patients with well-differentiated tumors had statistically fewer local recurrences (0% vs 22%, p = 0.036) if they were transfused perioperatively. However, the difference in distant metastases (0% vs 11%) was not statistically significant (p = 0.21). In contrast, patients with moderately and poorly differentiated disease receiving transfusions had more local recurrences and metastases, though this was not statistically significant. Our data suggest that there is no obvious evidence that perioperative blood transfusions have an adverse effect on local recurrence or distant metastases for iodine-125 seed implantation of carcinoma of the prostate.
在一些回顾性研究中，肿瘤手术期间的围手术期输血已被证明可缩短手术与癌症局部和/或远处复发之间的时间间隔。本研究调查了108例接受前列腺碘-125粒子植入和淋巴结清扫术治疗的局限性前列腺癌患者围手术期输血对疾病的相关影响（若存在影响的话）。对所有受试者进行分析时，输血组和未输血组之间的局部和远处失败情况无统计学差异。高分化肿瘤患者若在围手术期接受输血，其局部复发在统计学上较少（0%对22%，p = 0.036）。然而，远处转移的差异（0%对11%）无统计学意义（p = 0.21）。相比之下，中低分化疾病患者接受输血后局部复发和转移更多，尽管这无统计学意义。我们的数据表明，没有明显证据显示围手术期输血对前列腺癌碘-125粒子植入的局部复发或远处转移有不良影响。
