脑损伤后神经元细胞的再生。
Regeneration of neuronal cells following cerebral injury.
作者信息
Dailey Travis, Tajiri Naoki, Kaneko Yuji, Borlongan Cesar V
机构信息
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, Tampa, FL 33612, USA.
出版信息
Front Neurol Neurosci. 2013;32:54-61. doi: 10.1159/000346407. Epub 2013 Jul 8.
Abstract
Stem cells possess a definitive role in neuronal rejuvenation following a cerebral injury. Whether endogenous, from the neurogenic niches of the subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation, accumulating evidence demonstrates that stem cells ameliorate the consequences of cerebrovascular events, particularly cerebral ischemia. In this chapter, we review milestone studies implicating the role of stem cells in response to disease. Furthermore, we outline specific mechanisms of action along with their clinical potential as therapeutic treatments for ischemic stroke.
摘要
干细胞在脑损伤后的神经元修复中具有决定性作用。无论是内源性的，来自脑室下区和颗粒下区的神经发生微环境，还是通过外周循环从骨髓募集而来，越来越多的证据表明，干细胞可改善脑血管事件的后果，尤其是脑缺血。在本章中，我们回顾了涉及干细胞在应对疾病中作用的里程碑式研究。此外，我们概述了其具体作用机制及其作为缺血性中风治疗方法的临床潜力。
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Front Neurol Neurosci. 2013;32:54-61. doi: 10.1159/000346407. Epub 2013 Jul 8.
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本文引用的文献
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Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells.细胞疗法治疗中风：重点在于优化内皮祖细胞的安全性和疗效特征。
Curr Pharm Des. 2012;18(25):3731-4. doi: 10.2174/138161212802002733.
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The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders.骨髓源性干细胞向缺血性脑的巨大迁移：对中风和其他神经障碍的治疗意义。
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Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!骨髓干细胞动员在中风中的应用：“愚笨”也许是有益的！
Leukemia. 2011 Nov;25(11):1674-86. doi: 10.1038/leu.2011.167. Epub 2011 Jul 5.
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Stem cells for neural regeneration--a potential application of very small embryonic-like stem cells.神经再生的干细胞——极小胚胎样干细胞的一种潜在应用。
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The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization.脑-骨-血三联征：干细胞归巢和动员的交通信号灯。
Hematology Am Soc Hematol Educ Program. 2010;2010:1-6. doi: 10.1182/asheducation-2010.1.1.
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Optimization of isolation and further characterization of umbilical-cord-blood-derived very small embryonic/ epiblast-like stem cells (VSELs).优化分离和进一步鉴定脐带血来源的极小胚胎样干细胞（VSELs）。
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Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system.造血干细胞很“敏感”：神经系统对未成熟人类CD34+细胞的直接和间接调控
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Updates on stem cells and their applications in regenerative medicine.干细胞及其在再生医学中的应用进展
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Potential of stem/progenitor cells in treating stroke: the missing steps in translating cell therapy from laboratory to clinic.干细胞/祖细胞治疗中风的潜力：将细胞疗法从实验室转化到临床过程中缺失的环节。
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