Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 405 North Mathews, Urbana, Illinois 61801, USA.
J Acoust Soc Am. 2013 Jul;134(1):686-93. doi: 10.1121/1.4807576.
Simple scattering media fit scattering model theories much better than more complex scattering media. Tissue is much more complex as an acoustic scattering media and to date there has not been an adequate scattering model that fits it well. Previous studies evaluated the scattering characteristics of simple media (grouping of cells at various number densities) and fit them to the concentric spheres scattering model theory. This study is to increase the complexity of the media to provide insight into the acoustic scattering characteristics of tissue, and specifically two tumor types. Complementing the data from the tumors is 100% volume fraction cell pellets of the same cell lines. Cell pellets and ex vivo tumors are scanned using high-frequency single-element transducers (9-105 MHz), and the attenuation and backscatter coefficient (BSC) are estimated. BSC comparisons are made between cell pellets and tumors. The results show that the 4T1 (ATCC #CRL-2539) cell pellets and tumors have similar BSC characteristics, whereas the MAT (ATCC #CRL-1666) cell pellets and tumors have significantly different BSC characteristics. Factors that yield such differences are explored. Also, the fluid-filled sphere and the concentric spheres models are evaluated against the BSC characteristics, demonstrating that further work is required.
简单的散射介质比更复杂的散射介质更符合散射模型理论。组织作为一种声学散射介质要复杂得多，到目前为止，还没有一个合适的散射模型能够很好地拟合它。以前的研究评估了简单介质（不同数密度的细胞群）的散射特性，并将其拟合到同心球散射模型理论中。本研究旨在增加介质的复杂性，深入了解组织的声学散射特性，特别是两种肿瘤类型。肿瘤的补充数据是相同细胞系的 100%体积分数细胞球。细胞球和离体肿瘤使用高频单元件换能器（9-105 MHz）进行扫描，并估计衰减和反向散射系数（BSC）。比较了细胞球和肿瘤之间的 BSC。结果表明，4T1（ATCC #CRL-2539）细胞球和肿瘤具有相似的 BSC 特征，而 MAT（ATCC #CRL-1666）细胞球和肿瘤具有明显不同的 BSC 特征。探讨了产生这些差异的因素。此外，还评估了充满流体的球体和同心球体模型与 BSC 特性的吻合程度，表明需要进一步研究。
