Oelze Michael L, Zachary James F
Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering, University of Illinois, Urbana, IL 61801, USA.
Ultrasound Med Biol. 2006 Nov;32(11):1639-48. doi: 10.1016/j.ultrasmedbio.2006.05.006.
Two mouse models of mammary cancer (a carcinoma and sarcoma) were examined using quantitative ultrasound (QUS). Scatterer property estimates, i.e., the average scatterer diameter (ASD) and average acoustic concentration (AAC), were estimated from regions-of-interest (ROIs) inside the tumors. Initially, the spherical Gaussian model was used over an analysis bandwidth of 10 to 25 MHz to obtain ASD and AAC estimates. ASD estimates were 31.7 +/- 9.36 microm and 31.0 +/- 7.20 microm for the carcinomas and sarcomas, respectively. AAC estimates were 6.77 +/- 8.75 dB[mm(-3)] and 9.87 +/- 9.24 dB[mm(-3)], respectively. The initial ASD and AAC estimates did not yield statistically significant differences between the two kinds of tumors (p = 0.83, 0.86 for the ASD and AAC estimates, respectively). However, optical photomicrographs revealed distinct morphologic differences between the tumors. F-tests on the average power spectra from the tumors revealed statistically significant differences between the spectra over the range of 16 to 25 MHz. ASD and AAC estimates using the spherical Gaussian model were then obtained over the new analysis bandwidth of 16 to 25 MHz. The new ASD estimates were 42.1 +/- 4.01 microm and 32.1 +/- 3.81 microm for the carcinomas and sarcomas, respectively. The new AAC estimates were 16.4 +/- 17.1 dB[mm(-3)] and 36.4 +/- 11.9 dB[mm(-3)], respectively. Statistically significant differences were observed for both the ASD and AAC estimates when using the new analysis bandwidth. Structural differences between the tumors were revealed by both QUS and optical photomicrographs.
使用定量超声（QUS）对两种乳腺癌小鼠模型（一种癌模型和一种肉瘤模型）进行了检查。从肿瘤内部的感兴趣区域（ROI）估计散射体特性，即平均散射体直径（ASD）和平均声浓度（AAC）。最初，在10至25 MHz的分析带宽上使用球形高斯模型来获得ASD和AAC估计值。癌模型和肉瘤模型的ASD估计值分别为31.7±9.36微米和31.0±7.20微米。AAC估计值分别为6.77±8.75 dB[mm(-3)]和9.87±9.24 dB[mm(-3)]。最初的ASD和AAC估计值在两种肿瘤之间未产生统计学上的显著差异（ASD和AAC估计值的p值分别为0.83和0.86）。然而，光学显微照片显示了肿瘤之间明显的形态学差异。对肿瘤平均功率谱的F检验显示，在16至25 MHz范围内的光谱之间存在统计学上的显著差异。然后在16至25 MHz的新分析带宽上使用球形高斯模型获得ASD和AAC估计值。癌模型和肉瘤模型的新ASD估计值分别为42.1±4.01微米和32.1±3.81微米。新的AAC估计值分别为16.4±17.1 dB[mm(-3)]和36.4±11.9 dB[mm(-3)]。使用新的分析带宽时，ASD和AAC估计值均观察到统计学上的显著差异。QUS和光学显微照片均揭示了肿瘤之间的结构差异。
