一名患有免疫球蛋白A骨髓瘤患者体内万古霉素的蛋白结合情况。
Protein binding of vancomycin in a patient with immunoglobulin A myeloma.
作者信息
Cantú T G, Dick J D, Elliott D E, Humphrey R L, Kornhauser D M
机构信息
Department of Pharmacy, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, Maryland 21205.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1459-61. doi: 10.1128/AAC.34.7.1459.
Abstract
Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.
摘要
在一名免疫球蛋白A骨髓瘤患者中观察到非典型的万古霉素药代动力学。血清中的药物浓度极度升高，尽管肾功能正常，但消除半衰期延长，且万古霉素治疗无效。万古霉素的广泛结合，推测是由于高浓度的异常免疫球蛋白A蛋白，可能是导致这些观察结果的原因。
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本文引用的文献
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