Unidad de Biomedicina, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico D.F., Mexico; and.
J Lipid Res. 2013 Oct;54(10):2795-9. doi: 10.1194/jlr.M040584. Epub 2013 Jul 17.
Studies in mature adults suggest that the plasma concentration ratio of triglyceride (TG)/HDL-cholesterol (HDL-C) provides a simple way to identify apparently healthy individuals who are insulin resistant (IR) and at increased cardiometabolic risk. This study extends these observations by examining the clinical utility of the TG/HDL-C ratio and the metabolic syndrome (MetS) in 2,244 healthy college students (17-24 years old) of Mexican Mestizo ancestry. The TG/HDL-C ratio separating the 25% with the highest value was used to identify IR and increased cardiometabolic risk. Cardiometabolic risk factors were more adverse in men and women whose TG/HDL-C ratios exceeded 3.5 and 2.5, respectively, and approximately one third were identified as being IR. The MetS identified fewer individuals as being IR, but their risk profile was accentuated. In conclusion, both a higher TG/HDL-C ratio and a diagnosis of the MetS identify young IR individuals with an increased cardiometabolic risk profile. The TG/HDL-C ratio identified a somewhat greater number of "high risk" subjects, whereas the MetS found a group whose risk profile was somewhat magnified. These findings suggest that the TG/HDL-C ratio may serve as a simple and clinically useful approach to identify apparently healthy, young individuals who are IR and at increased cardiometabolic risk.
研究表明，成年人的甘油三酯（TG）/高密度脂蛋白胆固醇（HDL-C）血浆浓度比值可作为一种简单的方法，用于识别胰岛素抵抗（IR）和代谢心血管风险增加的貌似健康个体。本研究通过检查墨西哥梅斯蒂索人 2244 名健康大学生（17-24 岁）的 TG/HDL-C 比值和代谢综合征（MetS）的临床应用，扩展了这些观察结果。使用 TG/HDL-C 比值来分离最高值的 25%，以识别 IR 和增加的代谢心血管风险。在 TG/HDL-C 比值超过 3.5 和 2.5 的男性和女性中，代谢心血管危险因素更为不利，约有三分之一的人被认为是 IR。MetS 识别出的 IR 人数较少，但他们的风险特征更为明显。总之，较高的 TG/HDL-C 比值和 MetS 的诊断均可识别出代谢心血管风险增加的年轻 IR 个体。TG/HDL-C 比值识别出了更多的“高危”受试者，而 MetS 则发现了一组风险特征略有放大的受试者。这些发现表明，TG/HDL-C 比值可能是一种简单且具有临床意义的方法，可用于识别貌似健康、代谢心血管风险增加的年轻 IR 个体。
