Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor, Lambeth Wing, St. Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, United Kingdom,
J Nucl Cardiol. 2013 Oct;20(5):860-70; quiz 857-9, 871-3. doi: 10.1007/s12350-013-9762-7. Epub 2013 Jul 19.
Recent studies have demonstrated that a detailed knowledge of the extent of angiographic coronary artery disease (CAD) is not a prerequisite for clinical decision making, and the clinical management of patients with CAD is more and more focused towards the identification of myocardial ischemia and the quantification of ischemic burden. In this view, non-invasive assessment of ischemia and in particular stress imaging techniques are emerging as preferred and non-invasive options. A quantitative assessment of regional myocardial perfusion can provide an objective estimate of the severity of myocardial injury and may help clinicians to discriminate regions of the heart that are at increased risk for myocardial infarction. Positron emission tomography (PET) has established itself as the reference standard for myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) quantification. Cardiac magnetic resonance (CMR) is increasingly used to measure MBF and MPR by means of first-pass signals, with a well-defined diagnostic performance and prognostic value. The aim of this article is to review the currently available evidence on the use of both PET and CMR for quantification of MPR, with particular attention to the studies that directly compared these two diagnostic methods.
最近的研究表明，详细了解血管造影冠状动脉疾病 (CAD) 的程度并不是临床决策的前提条件，CAD 患者的临床管理越来越侧重于确定心肌缺血和量化缺血负担。在这种情况下，非侵入性评估缺血，特别是应激成像技术，正在成为首选的非侵入性选择。对局部心肌灌注的定量评估可以提供心肌损伤严重程度的客观估计，并有助于临床医生区分心脏处于心肌梗死风险增加的区域。正电子发射断层扫描 (PET) 已成为心肌血流 (MBF) 和心肌灌注储备 (MPR) 定量的参考标准。心脏磁共振 (CMR) 越来越多地用于通过首过信号测量 MBF 和 MPR，具有明确的诊断性能和预后价值。本文的目的是回顾目前关于使用 PET 和 CMR 进行 MPR 定量的可用证据，特别关注直接比较这两种诊断方法的研究。
