维生素 A 补充对接受干扰素 β-1a（Avonex）治疗的多发性硬化症患者中维甲酸相关孤儿受体 γt（RORγt）和白细胞介素-17（IL-17）基因表达的影响。
The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.
机构信息
Cellular and Molecular Nutrition Department, School of Nutritional Sciences and Dietetics, Tehran university of Medical Sciences, Tehran, Iran.
出版信息
J Mol Neurosci. 2013 Nov;51(3):749-53. doi: 10.1007/s12031-013-0058-9. Epub 2013 Jul 19.
The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.
本研究旨在探讨维生素 A 对多发性硬化症患者 RORγt 和 IL-17 基因表达的作用。维生素 A 组患者每天接受 25,000IU 视黄醇棕榈酸酯，而安慰剂组患者每天服用一粒安慰剂，为期 6 个月。在研究开始和结束时通过实时 PCR 测量基因表达。本研究结果表明，维生素 A 下调 IL-17 和 RORγt 基因表达。安慰剂组基因表达无变化。
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