Fukunaga M, Silverberg S G
Department of Pathology, George Washington University Medical Center, Washington, D.C. 20037.
Cancer. 1990 Aug 15;66(4):758-64. doi: 10.1002/1097-0142(19900815)66:4<758::aid-cncr2820660427>3.0.co;2-h.
The DNA content of formalin-fixed, paraffin-embedded tissue from 21 patients (26 lesions) with Kaposi's sarcoma associated with acquired immune deficiency syndrome (AIDS) was analyzed by flow cytometry. The lesions were classified histologically into the following three types according to the predominant pattern: granulation tissue-like (two lesions), angioma/angiosarcoma-like (ten lesions), and spindle cell (14 lesions). All lesions showed exclusively DNA diploidy, and the S- phase fractions were usually low, ranging from 2% to 13% (mean, 6.9%). The follow-up periods were from 2 to 60 months. Five patients died, with one of the deaths attributed to pulmonary failure resulting from diffuse alveolar damage and Kaposi's sarcoma; the other deaths were attributed to infections. These results indicate that Kaposi's sarcoma is not a high-grade neoplasm and, combined with previously reported evidence, may suggest that Kaposi's sarcoma associated with AIDS is a proliferative process rather than a malignant neoplasm.
采用流式细胞术分析了21例获得性免疫缺陷综合征（AIDS）相关卡波西肉瘤患者（26个病灶）福尔马林固定、石蜡包埋组织的DNA含量。根据主要形态，病灶在组织学上分为以下三种类型：肉芽组织样（2个病灶）、血管瘤/血管肉瘤样（10个病灶）和梭形细胞（14个病灶）。所有病灶均表现为单纯的DNA二倍体，S期分数通常较低，范围为2%至13%（平均6.9%）。随访时间为2至60个月。5例患者死亡，其中1例死于弥漫性肺泡损伤和卡波西肉瘤导致的呼吸衰竭；其他死亡归因于感染。这些结果表明，卡波西肉瘤不是高级别肿瘤，结合先前报道的证据，可能提示与AIDS相关的卡波西肉瘤是一个增殖过程而非恶性肿瘤。
