Sanchez M A, Ames E D, Erhardt K, Auer G U
Department of Pathology, Englewood Hospital, New Jersey 07631.
Anal Quant Cytol Histol. 1988 Feb;10(1):16-20.
While Kaposi's sarcoma in patients with the acquired immune deficiency syndrome (AIDS) may present as a multicentric disease with progressive organ involvement, the classic form of Kaposi's sarcoma is an indolent tumor seldom affecting extracutaneous areas and almost never responsible for the patient's demise. An attempt was made to correlate these clinical differences with the nuclear DNA content of tumor cells in histologic sections from 15 patients (9 with AIDS and 6 without AIDS). All tumors showed a similar DNA distribution pattern, with most cells appearing diploid, indicative of a low malignant potential. These findings indicate that Kaposi's sarcoma of both AIDS and non-AIDS patients is a tumor of intrinsically low malignancy and that lack of immune surveillance is most probably responsible for its aggressive biologic behavior in many AIDS patients.
虽然获得性免疫缺陷综合征（艾滋病）患者的卡波西肉瘤可能表现为多中心疾病并伴有进行性器官受累，但经典型卡波西肉瘤是一种进展缓慢的肿瘤，很少累及皮肤外区域，几乎从不导致患者死亡。我们试图将这些临床差异与15例患者（9例艾滋病患者和6例非艾滋病患者）组织学切片中肿瘤细胞核DNA含量进行关联。所有肿瘤均呈现相似的DNA分布模式，大多数细胞为二倍体，提示恶性潜能较低。这些发现表明，艾滋病患者和非艾滋病患者的卡波西肉瘤本质上都是恶性程度较低的肿瘤，免疫监视功能的缺失很可能是其在许多艾滋病患者中表现出侵袭性生物学行为的原因。
