Fukunaga M, Endo Y, Masui F, Yoshikawa T, Ishikawa E, Ushigome S
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
Virchows Arch. 1996 Jul;428(4-5):301-4. doi: 10.1007/BF00196705.
A case of retiform haemangioendothelioma (RH), a recently described rare cutaneous low-grade angiosarcoma, is presented. A 75-year-old female had a 3.5 cm cutaneous nodule in her right lower thigh with 10 year preoperative duration. Microscopically, the dermis and subcutis contained a diffuse and infiltrative neoplasm which was characterized by long arborizing blood vessels arranged in a retiform pattern lined by cuboidal and flattened cells, occasional hobnail appearance of endothelial cells, and a prominent small lymphocytic infiltrate. Small solid areas were also found. Neither significant cellular atypia nor mitotic activity was observed. Immunohistochemically, the tumour cells reacted with endothelial markers (CD31, CD34, factor-VIII-related antigen) and bound Ulex europaeus agglutinin 1. There was no pericytic component within the tumour. The tumour was diploid by flow cytometry. The patient had a local recurrence 27 months after the excision. These findings support the view that RH is a low-grade angiosarcoma and indicate that RH must be distinguished from conventional angiosarcoma.
本文报告一例网状血管内皮瘤（RH），这是一种最近才被描述的罕见皮肤低度血管肉瘤。一名75岁女性右大腿下部有一个3.5厘米的皮肤结节，术前病程为10年。显微镜下，真皮和皮下组织有一个弥漫性浸润性肿瘤，其特征是长的分支状血管呈网状排列，内衬立方状和平扁状细胞，内皮细胞偶尔呈鞋钉样外观，并有明显的小淋巴细胞浸润。还发现了小的实性区域。未观察到明显的细胞异型性和有丝分裂活性。免疫组化显示，肿瘤细胞与内皮标记物（CD31、CD34、VIII因子相关抗原）反应，并结合荆豆凝集素1。肿瘤内无周细胞成分。流式细胞术显示肿瘤为二倍体。患者切除术后27个月出现局部复发。这些发现支持RH是低度血管肉瘤的观点，并表明RH必须与传统血管肉瘤相鉴别。
