犬颅内脑膜瘤或神经胶质瘤放射治疗后的结果。
Outcome After Radiation Therapy in Canine Intracranial Meningiomas or Gliomas.
机构信息
Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.
Southfields Veterinary Specialists (formerly VRCC Veterinary Referrals), Essex, U.K.
出版信息
In Vivo. 2021 Mar-Apr;35(2):1117-1123. doi: 10.21873/invivo.12357.
AIM
To characterize a group of dogs diagnosed with meningioma or glioma treated with radiation therapy and assess the clinical impact of diagnosis and radiation protocol on survival time.
PATIENTS AND METHODS
Canine patient records from a single veterinary referral hospital, between 2011 and 2015, were searched for intracranial tumour cases treated with radiation therapy, as a sole modality. Thirty-two dogs were included.
RESULTS
Median survival times were 524 days [95% confidence interval (CI)=287-677] in total, 512 days (95% CI=101-682) for the glioma group and 536 days (95% CI=249-677) for the meningioma group. No significant difference in survival was detected when using a definitive or a palliative protocol (p=0.130), nor other prognostic factors were found.
CONCLUSION
Our results highlight the efficacy of radiation therapy in the treatment of canine meningioma, as well as glioma, suggesting a change in the current perception of the response of glial tumours to radiation.
目的
对一组接受放射治疗的诊断为脑膜瘤或神经胶质瘤的犬进行描述，并评估诊断和放射方案对生存时间的临床影响。
患者和方法
在 2011 年至 2015 年间，对一家兽医转诊医院的犬类患者记录进行了搜索，以寻找接受单纯放射治疗的颅内肿瘤病例。共纳入 32 只犬。
结果
总生存时间中位数为 524 天[95%置信区间（CI）=287-677]，神经胶质瘤组为 512 天（95%CI=101-682），脑膜瘤组为 536 天（95%CI=249-677）。使用确定性或姑息性方案时，未检测到生存时间的显著差异（p=0.130），也未发现其他预后因素。
结论
我们的结果强调了放射治疗对犬脑膜瘤以及神经胶质瘤治疗的疗效，这表明目前对胶质肿瘤对放射的反应的认识可能需要改变。
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