Roy P, Day L, Sowton E
Br Med J. 1975 Jul 26;3(5977):195-7. doi: 10.1136/bmj.3.5977.195.
In 11 patients with severe angina pectoris a new beta-blocking drug, atenolol (Tenormin; I.C.I.66082), was found in a double-blind randomized trial to reduce significantly the frequency of anginal attacks (P less than 0-001) and the amount of trinitrin consumed (P less than 0-03) in comparison with practolol and placebo. There was no significant improvement in the patients' ability to exercise on the bicycle ergometer.
在一项双盲随机试验中，对11例严重心绞痛患者使用一种新型β受体阻滞剂阿替洛尔（氨酰心安；ICI66082），结果发现与心得宁及安慰剂相比，阿替洛尔能显著减少心绞痛发作频率（P<0.001）和硝酸甘油消耗量（P<0.03）。但患者在自行车测力计上的运动能力并无显著改善。
