Division of Translational Research and Applied Statistics, Department of Public Health Sciences University of Virginia, Charlottesville, VA 22908, USA.
Comput Methods Programs Biomed. 2013 Oct;112(1):211-8. doi: 10.1016/j.cmpb.2013.05.020. Epub 2013 Jul 18.
This paper presents the R package pocrm for implementing and simulating the partial order continual reassessment method (PO-CRM; [1,2]) in Phase I trials of combinations of agents. The aim of this article is to illustrate, through examples of the pocrm package, how the PO-CRM works and how its operating characteristics can inform clinical trial investigators. This should promote the use of the PO-CRM in designing and conducting dose-finding Phase I trials of combinations of agents.
本文介绍了用于在联合用药的 I 期试验中实施和模拟部分有序持续评估方法（PO-CRM；[1,2]）的 R 包 pocrm。本文的目的是通过 pocrm 包的示例来说明 PO-CRM 的工作原理及其操作特性如何为临床试验研究者提供信息。这将有助于推广 PO-CRM 在联合用药的剂量探索 I 期试验中的应用。
