Mayo Clinic in Arizona, 13400 East Shea Boulevard, Scottsdale, AZ, USA.
Blood Cancer J. 2013 Jul 19;3(7):e127. doi: 10.1038/bcj.2013.26.
Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
下一代测序技术在血液恶性肿瘤的研究中引发了一场革命，在过去几年中发表了大量的研究成果和发现。这项强大的技术带来了与疾病诊断、风险分层、克隆进化和治疗干预相关的重大发现。作为后基因组时代的一部分，测序分析可能会成为常规临床检测的一部分，最终的挑战将是成功地将基因发现转化为预防和治疗干预，作为个体化医学策略的一部分。在本报告中，我们回顾了通过全基因组序列分析对血液恶性肿瘤的认识的最新进展。
