Verhaegen J, Glupczynski Y, Verbist L, Blogie M, Vandeven J, Yourassowsky E, Vandepitte J
Department of Microbiology, Universitaire Ziekenhuizen, Leuven, Belgium.
Eur J Clin Microbiol Infect Dis. 1990 Jun;9(6):390-5. doi: 10.1007/BF01979467.
A total of 2,765 strains of Streptococcus pneumoniae isolated in more than 60 Belgian laboratories from blood or normally sterile body fluids between 1 November 1980 and 31 December 1988 were serotyped. From January 1983 onwards susceptibility of the strains to antimicrobial agents was also tested. The 2,765 isolates belonged to 57 of the 84 currently identified serotypes. Overall, 94% of the strains were represented in the current 23-valent vaccine. The remaining 6% of strains were distributed among 18 serotypes. More than 84% of the middle ear fluid isolates came from children under ten years. Meningitis was commonest in children under five years and in adults over sixty years. Two-thirds of pneumococcal bacteremia isolates came from patients over 50 years. Of 1,933 isolates tested for susceptibility to antibiotics, 335 (17%) were resistant to one or more of the agents tested (tetracycline, erythromycin, chloramphenicol, penicillin). Only 19 strains were relatively resistant to penicillin, while six were fully resistant. Resistance to erythromycin increased significantly from 5.2% in 1986 to 11.5% in 1988. The resistance of Streptococcus pneumoniae to other antimicrobial agents did not change significantly during the study period. There was no relationship between age group and resistance to any of the agents tested.
1980年11月1日至1988年12月31日期间，比利时60多个实验室从血液或通常无菌的体液中分离出共2765株肺炎链球菌，并进行了血清分型。从1983年1月起，还对这些菌株进行了对抗菌药物的敏感性测试。这2765株分离株属于目前已确定的84种血清型中的57种。总体而言，94%的菌株包含在目前的23价疫苗中。其余6%的菌株分布在18种血清型中。超过84%的中耳液分离株来自10岁以下儿童。脑膜炎在5岁以下儿童和60岁以上成年人中最为常见。三分之二的肺炎球菌血症分离株来自50岁以上的患者。在1933株接受抗生素敏感性测试的分离株中，335株（17%）对一种或多种测试药物（四环素、红霉素、氯霉素、青霉素）耐药。只有19株对青霉素相对耐药，6株完全耐药。对红霉素的耐药率从1986年的5.2%显著增加到1988年的11.5%。在研究期间，肺炎链球菌对其他抗菌药物的耐药性没有显著变化。年龄组与对任何测试药物的耐药性之间没有关联。
