Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
Adv Healthc Mater. 2014 Jan;3(1):133-41. doi: 10.1002/adhm.201300189. Epub 2013 Jul 22.
A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nanoconstruct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body.
本文提出了一种新型的代谢型高效癌症放射治疗增敏剂，将超小的金纳米团簇（<2nm）与生物相容性的涂层配体（谷胱甘肽，GSH）相结合。这种新的纳米结构（GSH 包裹的 Au25 NCs）继承了金核（强烈的放射增敏作用）和 GSH 壳（良好的生物相容性）的优点。它可以通过改进的 EPR 效应优先在肿瘤中积累，从而对癌症放射治疗有强烈的增强作用。治疗后，小尺寸的 GSH-Au25 NCs 可以被肾脏有效清除，最大限度地减少由于 Au25 NCs 在体内积累而产生的任何潜在副作用。
