CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India.
Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA.
Int J Nanomedicine. 2018 Mar 15;13(T-NANO 2014 Abstracts):113-115. doi: 10.2147/IJN.S125006. eCollection 2018.
Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines.
金纳米颗粒由于其高辐射吸收系数和高效产生二次光电子，被预测可以增强放射治疗的疗效。然而，为了达到有效的治疗效果，需要使用高剂量的金纳米颗粒，这限制了其应用。我们合成了多功能金纳米团簇（GNCs），可用于成像和放射治疗。对设计的 GNCs 的物理化学性质、生物相容性以及它们在 PC3 细胞系中的辐射剂量增强潜力进行了表征。
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