Kim Ju Yeong, Yi Gwang, Kim Yeo Rang, Chung Jae Yeon, Ahn Ji Hyun, Uhm You Kyoung, Jee Byung Chul, Suh Chang Suk, Kim Seok Hyun
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
Clin Exp Reprod Med. 2013 Jun;40(2):95-9. doi: 10.5653/cerm.2013.40.2.95. Epub 2013 Jun 30.
To evaluate the correlation between serum levels of anti-Müllerian hormone (AMH) and ovarian response to mild stimulation in normoovulatory women and anovulatory women with polycystic ovary syndrome (PCOS).
Seventy-four cycles of mild stimulation (clomiphene citrate+gonadotropin followed by timed intercourse or intrauterine insemination) performed in normoovulatory women (57 cycles) and anovulatory women with PCOS (17 cycles). Ovarian sensitivity was defined by the number of mature follicles (≥14 mm) on triggering day per 100 IU of gonadotropin. A correlation between ovarian sensitivity and the baseline serum AMH level (absolute or multiples of the median [MoM] value for each corresponding age) was calculated. Correlation between ovarian response and serum AMH level was evaluated.
Ovarian sensitivity to mild stimulation was positively correlated with absolute serum AMH (r=0.535, p<0.001) or AMH-MoM value (r=0.390, p=0.003) in normoovulatory women, but this correlation was not observed in anovulatory women with PCOS (r=0.105, p>0.05, r=-0.265, p>0.05, respectively).
Ovarian response to mild stimulation is possibly predicted by the serum AMH level in normoovulatory women, but not in anovulatory women with PCOS.
评估正常排卵女性和多囊卵巢综合征（PCOS）无排卵女性血清抗苗勒管激素（AMH）水平与卵巢对轻度刺激反应之间的相关性。
对正常排卵女性（57个周期）和PCOS无排卵女性（17个周期）进行了74个周期的轻度刺激（枸橼酸氯米芬+促性腺激素，随后进行定时性交或宫腔内人工授精）。卵巢敏感性通过触发日每100 IU促性腺激素的成熟卵泡（≥14 mm）数量来定义。计算卵巢敏感性与基线血清AMH水平（每个相应年龄的绝对值或中位数倍数[MoM]值）之间的相关性。评估卵巢反应与血清AMH水平之间的相关性。
在正常排卵女性中，卵巢对轻度刺激的敏感性与血清AMH绝对值（r=0.535，p<0.001）或AMH-MoM值（r=0.390，p=0.003）呈正相关，但在PCOS无排卵女性中未观察到这种相关性（分别为r=0.105，p>0.05；r=-0.265，p>0.05）。
正常排卵女性中，血清AMH水平可能预测卵巢对轻度刺激的反应，但PCOS无排卵女性并非如此。
