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本文引用的文献

1
Effect of fulvic and humic acids on performance, immune response and thyroid function in rats.腐殖酸和黄腐酸对大鼠生产性能、免疫应答和甲状腺功能的影响。
J Anim Physiol Anim Nutr (Berl). 2010 Dec;94(6):721-8. doi: 10.1111/j.1439-0396.2010.01023.x.
2
Glucan and humic acid: synergistic effects on the immune system.葡聚糖和腐殖酸：对免疫系统的协同作用。
J Med Food. 2010 Aug;13(4):863-9. doi: 10.1089/jmf.2009.0178.
3
Humic acid induced genotoxicity in human peripheral blood lymphocytes using comet and sister chromatid exchange assay.使用彗星试验和姐妹染色单体交换试验研究腐殖酸对人外周血淋巴细胞的遗传毒性。
J Hazard Mater. 2008 May 1;153(1-2):784-91. doi: 10.1016/j.jhazmat.2007.09.024. Epub 2007 Sep 8.
4
Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue.用海带多糖（一种可发酵的海洋β-（1-3）-葡聚糖）进行膳食补充，可通过调节肝组织中的免疫反应来保护大鼠免受脂多糖诱导的肝毒性。
Int Immunopharmacol. 2007 Dec 5;7(12):1497-506. doi: 10.1016/j.intimp.2007.06.011. Epub 2007 Jul 17.
5
Procathepsin D secreted by HaCaT keratinocyte cells - A novel regulator of keratinocyte growth.HaCaT角质形成细胞分泌的组织蛋白酶原D——角质形成细胞生长的新型调节因子。
Eur J Cell Biol. 2007 Jun;86(6):303-13. doi: 10.1016/j.ejcb.2007.03.008.
6
Activation of Ah receptor by pure humic acids.纯腐殖酸对芳烃受体的激活作用。
Environ Toxicol. 2006 Aug;21(4):338-42. doi: 10.1002/tox.20185.
7
An alpha-glucan of Pseudallescheria boydii is involved in fungal phagocytosis and Toll-like receptor activation.博伊德假阿利什菌的一种α-葡聚糖参与真菌吞噬作用和Toll样受体激活。
J Biol Chem. 2006 Aug 11;281(32):22614-23. doi: 10.1074/jbc.M511417200. Epub 2006 Jun 9.
8
Changes in iodine excretion in 50-69-y-old denizens of an Arctic society in transition and iodine excretion as a biomarker of the frequency of consumption of traditional Inuit foods.转型期北极社会50至69岁居民碘排泄量的变化以及碘排泄作为传统因纽特食物消费频率生物标志物的研究
Am J Clin Nutr. 2005 Mar;81(3):656-63. doi: 10.1093/ajcn/81.3.656.
9
Investigation of the immunostimulatory properties of oxihumate.
Z Naturforsch C J Biosci. 2003 Mar-Apr;58(3-4):263-7. doi: 10.1515/znc-2003-3-421.
10
Increased efficiency of Lewis lung carcinoma chemotherapy with a macrophage stimulator--yeast carboxymethyl glucan.
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腐殖酸中脂肪族侧链上与氧烷基相关的基团的相对丰度与腐殖酸的主要药理多效性有关。

The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids.

机构信息

Department of Pathology, University of Louisville, Louisville, Kentucky 40202, USA.

出版信息

J Med Food. 2013 Jul;16(7):625-32. doi: 10.1089/jmf.2012.0212.

DOI:10.1089/jmf.2012.0212
PMID:23875902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3719442/
Abstract

Despite the rather common presence of humic acid (HA), our full knowledge of its biological effect is still lacking. In this article, we first performed a physicochemical characterization of several HAs, and next, we evaluated their ability to affect interleukin-2 secretion, antibody secretion, wound healing (an in vitro model using HaCaT cells), cancer growth (the Lewis lung carcinoma model), and protection against hepatotoxicity. In all tested reactions, HA showed significant stimulation on immune reactions, including suppression of cancer growth and inhibition of lipopolysaccharide-induced hepatotoxicity. These effects were dependent on its chemical properties. The pleiotropic effects of HA observed in this article suggest the possible role of these compounds in human nutrition.

摘要

尽管腐殖酸 (HA) 的存在相当普遍，但我们对其生物学效应的了解仍很欠缺。在本文中，我们首先对几种 HA 进行了理化特性分析，然后评估了它们对白细胞介素-2 分泌、抗体分泌、伤口愈合（使用 HaCaT 细胞的体外模型）、癌症生长（Lewis 肺癌模型）和肝毒性保护的影响。在所有测试的反应中，HA 对免疫反应表现出显著的刺激作用，包括抑制癌症生长和抑制脂多糖诱导的肝毒性。这些作用依赖于其化学特性。本文观察到的 HA 的多效性作用提示这些化合物可能在人类营养中发挥作用。