Department of Nephrology, Shenzhen Third People's Hospital, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
PLoS One. 2024 Aug 27;19(8):e0309026. doi: 10.1371/journal.pone.0309026. eCollection 2024.
Studies investigating the relationship between flavonoid intake and chronic kidney disease (CKD) are limited. This study investigated the association between daily flavonoid intake and CKD in US adults by using data for 2007-2008, 2009-2010, and 2017-2018 from the National Health and Nutrition Examination Survey (NHANES) database.
This study employed a cross-sectional design and used data from three cycles of the continuous NHANES: 2007-2008, 2009-2010, and 2017-2018. NHANES researchers collected data related to consumption of various food and beverages from participants by employing 24-h dietary recall questionnaires. CKD is defined as an estimated glomerular filtration rate of < 60 mL/min/1.73m2 or a urine albumin-to-creatinine ratio of ≥ 30 mg/g.
The odds ratios (OR) for CKD risk in the second (Q2), third (Q3), and fourth (Q4) quartiles of total flavonoid intake, compared with that in the first (Q1) quartile, were 0.780 (95% CI: 0.600, 1.015), 0.741 (95% CI: 0.573, 0.957), and 0.716 (95% CI: 0.554, 0.925), respectively (with a P value for the trend of 0.040). According to the restricted cubic spline analysis, total flavonoid intake exhibited a non-linear relationship with CKD risk (P < 0.001).
Our findings suggest that a potential J-shaped relationship was observed between total flavonoid consumption and CKD risk, with an inflection point at 69.58 mg/d. Our study indicates that a moderate intake of flavonoids may confer renal benefits which may offer novel strategies for CKD treatment.
关于黄酮类化合物摄入量与慢性肾脏病（CKD）之间关系的研究有限。本研究利用美国国家健康和营养调查（NHANES）数据库 2007-2008 年、2009-2010 年和 2017-2018 年的数据，调查了美国成年人每日黄酮类化合物摄入量与 CKD 之间的关系。
本研究采用横断面设计，使用来自三个连续 NHANES 周期的数据：2007-2008 年、2009-2010 年和 2017-2018 年。NHANES 研究人员通过 24 小时膳食回忆问卷收集参与者各种食物和饮料消费相关的数据。CKD 定义为估计肾小球滤过率 < 60 mL/min/1.73m2 或尿白蛋白/肌酐比≥ 30 mg/g。
与第一（Q1）四分位组相比，总黄酮摄入量第二（Q2）、第三（Q3）和第四（Q4）四分位组的 CKD 风险的比值比（OR）分别为 0.780（95%CI：0.600，1.015）、0.741（95%CI：0.573，0.957）和 0.716（95%CI：0.554，0.925）（趋势检验 P 值=0.040）。根据限制立方样条分析，总黄酮摄入量与 CKD 风险呈非线性关系（P<0.001）。
本研究结果表明，总黄酮类化合物的摄入量与 CKD 风险之间存在潜在的 J 形关系，拐点为 69.58mg/d。本研究表明，适度摄入黄酮类化合物可能对肾脏有益，这可能为 CKD 治疗提供新策略。
