Delport R, Ubbink J B, Bosman H, Bissbort S, Vermaak W J
Department of Chemical Pathology, University of Pretoria, South Africa.
Int J Vitam Nutr Res. 1990;60(1):35-40.
The effect of intravenous infusion of aminophylline, a strong inhibitor of pyridoxal kinase, on intra- and extracellular vitamin B6 homeostasis was investigated in four beagle dogs. Plasma and erythrocyte pyridoxal levels increased by 118% and 117% respectively after 3 hours of aminophylline infusion, (4 mg/kg body weight/hour), however, infusion of beta-hydroxyethyltheophylline, which does not inhibit pyridoxal kinase, had no effect on either intra- or extracellular vitamin B6 aldehyde derivative levels. It is suggested that theophylline induced pyridoxal kinase inhibition resulted in a disturbed equilibrium between pyridoxal and pyridoxal 5'-phosphate.
在四只比格犬中研究了静脉输注氨茶碱（一种吡哆醛激酶的强效抑制剂）对细胞内和细胞外维生素B6稳态的影响。输注氨茶碱（4毫克/千克体重/小时）3小时后，血浆和红细胞中的吡哆醛水平分别升高了118%和117%，然而，输注不抑制吡哆醛激酶的β-羟乙基茶碱对细胞内或细胞外维生素B6醛衍生物水平均无影响。提示茶碱诱导的吡哆醛激酶抑制导致了吡哆醛和5'-磷酸吡哆醛之间的平衡紊乱。
