Toda S, Sugawara K, Nishiyama Y, Ohbayashi M, Ohkusa N, Yamamoto H, Konishi M, Oki T
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
J Antibiot (Tokyo). 1990 Jul;43(7):796-808. doi: 10.7164/antibiotics.43.796.
Quinaldopeptin, a new type of quinomycin antibiotic, was isolated from the culture of Streptoverticillium album strain Q132-6. The antibiotic exhibited strong in vitro antimicrobial and cytotoxic activity and significantly prolonged the survival time of mice inoculated with a murine tumor. Quinaldopeptin is a symmetric cyclic peptide linked only by peptide bonds and differs from known antibiotics of the quinomycin family by the lack of ester linkage.
喹哪啶肽是一种新型的醌霉素类抗生素，从白色链霉菌Q132 - 6菌株的培养物中分离得到。该抗生素在体外表现出强大的抗菌和细胞毒性活性，并显著延长了接种鼠肿瘤小鼠的存活时间。喹哪啶肽是一种仅通过肽键连接的对称环肽，与已知的醌霉素家族抗生素不同，它缺乏酯键。
