Valtueña Jara, González-Gross Marcela, Huybrechts Inge, Breidenassel Christina, Ferrari Marika, Mouratidou Theodora, Gottrand Frederic, Dallongeville Jean, Azzini Elena, Sioen Isabelle, Gómez-Martínez Sonia, Cuenca-García Magdalena, Kersting Mathilde, Stehle Peter, Kafatos Anthony, Manios Yannis, Widhalm Kurt, Moreno Luis A
ImFine Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid.
J Nutr Sci Vitaminol (Tokyo). 2013;59(3):161-71. doi: 10.3177/jnsv.59.161.
Evidence indicates low 25-hydroxyvitamin D [(25(OH)D] concentrations in European adolescents. Identification of potential determinants is therefore essential to guide public health initiatives aiming at optimizing vitamin D status across Europe. The aim of the study was to identify potential influencing factors of 25(OH)D concentrations in European adolescents aged 12.5 to 17.5 y, participating in the multi-centre cross-sectional Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. A subset of 1,006 participants (46.8% males) was drawn from the main study. Measures of body composition, biochemical markers, socioeconomic status, dietary intake, physical activity, fitness, sleep time and vitamin D genetic polymorphism (rs1544410) were assessed. Stepwise multivariate linear regression analysis was conducted stratified by gender. In males, linear regression of 25(OH)D, suggested that (1) winter season (β=-0.364; p<0.01), (2) higher latitudes (β=-0.246; p<0.01), (3) BMI z-score (β=-0.198; p<0.05) and (4) retinol concentration (β=0.171; p<0.05) independently influenced 25(OH)D concentrations. In females, (1) winter season (β=-0.370; p<0.01), (2) sleep time (β=-0.231; p<0.01), (3) supplement intake (β=0.221; p<0.05), (4) flexibility (β=0.184; p<0.05), (5) body fat % (β=0.201; p<0.05) (6), BMI z-score (β=-0.272; p<0.05), (7) higher latitudes (β=-0.219; p<0.01) and (8) handgrip strength (β=0.206; p<0.05) independently influenced 25(OH)D concentrations. Season, latitude, fitness, adiposity, sleep time and micronutrient supplementation were highly related to 25(OH)D concentrations found in European adolescents.
有证据表明欧洲青少年的25-羟基维生素D[25(OH)D]浓度较低。因此，确定潜在的决定因素对于指导旨在优化全欧洲维生素D水平的公共卫生举措至关重要。本研究的目的是确定参与多中心横断面青少年营养欧洲健康生活方式（HELENA）研究的12.5至17.5岁欧洲青少年25(OH)D浓度的潜在影响因素。从主要研究中抽取了1006名参与者的一个子集（46.8%为男性）。评估了身体成分、生化指标、社会经济地位、饮食摄入、身体活动、体能、睡眠时间和维生素D基因多态性（rs1544410）。按性别分层进行逐步多元线性回归分析。在男性中，25(OH)D的线性回归表明，（1）冬季（β=-0.364；p<0.01），（2）较高纬度（β=-0.246；p<0.01），（3）BMI z评分（β=-0.198；p<0.05）和（4）视黄醇浓度（β=0.171；p<0.05）独立影响25(OH)D浓度。在女性中，（1）冬季（β=-0.370；p<0.01），（2）睡眠时间（β=-0.231；p<0.01），（3）补充剂摄入（β=0.221；p<0.05），（4）柔韧性（β=0.184；p<0.05），（5）体脂百分比（β=0.201；p<0.05）（6），BMI z评分（β=-0.272；p<0.05），（7）较高纬度（β=-0.219；p<0.01）和（8）握力（β=0.206；p<0.05）独立影响25(OH)D浓度。季节、纬度、体能、肥胖、睡眠时间和微量营养素补充与欧洲青少年的25(OH)D浓度高度相关。
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