Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Cervi 93, I-20090 Segrate, Milano, Italy.
J Endocrinol Invest. 2013 Dec;36(11):1062-8. doi: 10.3275/9064. Epub 2013 Jul 23.
Mechanical overload and poor quality of contractile elements related to metabolic abnormalities concur to motor disability of obesity. The independent contribution of these factors to motor dysfunction in obese individuals is scarcely defined.
Aim of the study is to test the hypothesis that metabolic factors may independently affect motor function in obesity.
Leg maximum power output per unit body mass (W Mb), per unit fat-free mas (W FFM) and fatigue in daily functioning were assessed in 635 obese [body mass index (BMI)≥ 35 kg/m(2)] individuals (286 men, 349 women) aged 19-78 yr. The independent effects of age, BMI, insulin resistance and the five components of the metabolic syndrome on W Mb, W FFM and fatigue were evaluated by multivariate analysis.
A multiple regression analysis revealed that in both genders W Mb (denoting the individual's performance capability during anaerobic tasks) was independently reduced by age (p<0.001), BMI (p<0.05-0.001) and abnormalities of glucose metabolism (p<0.06-0.01), while W FFM (representing the muscle intrinsic anaerobic capability) was affected only by age (p<0.001) and glucose metabolism impairment (p<0.06-0.01). In both genders fatigue was increased by age (p<0.001) and BMI (p<0.05-0.01), but augmented by low levels of HDL-cholesterol in men only (p<0.05).
Besides depending on mechanical overload and age, low muscle power output in obese individuals was independently associated also with metabolic abnormalities related to impaired glucose homeostasis. Fatigue and performance, although similarly influenced by age and body mass excess, are affected by different metabolic factors.
与代谢异常相关的机械过载和收缩成分质量差共同导致肥胖患者的运动障碍。这些因素对肥胖个体运动功能障碍的独立贡献尚未明确界定。
本研究旨在检验代谢因素可能独立影响肥胖个体运动功能的假说。
对 635 名肥胖个体（BMI≥35kg/m²，286 名男性，349 名女性，年龄 19-78 岁）进行单位体重最大腿部功率输出（W Mb）、单位去脂体重最大腿部功率输出（W FFM）和日常活动疲劳评估。采用多元分析评估年龄、BMI、胰岛素抵抗和代谢综合征的五个组分对 W Mb、W FFM 和疲劳的独立影响。
多元回归分析显示，在两性中，W Mb（表示个体在无氧任务中的表现能力）均独立地受到年龄（p<0.001）、BMI（p<0.05-0.001）和葡萄糖代谢异常（p<0.06-0.01）的降低，而 W FFM（代表肌肉内在的无氧能力）仅受到年龄（p<0.001）和葡萄糖代谢受损（p<0.06-0.01）的影响。在两性中，疲劳均因年龄（p<0.001）和 BMI（p<0.05-0.01）增加而增加，但仅在男性中因低水平高密度脂蛋白胆固醇而增加（p<0.05）。
除了依赖于机械过载和年龄，肥胖个体的低肌肉功率输出还与葡萄糖稳态受损相关的代谢异常独立相关。疲劳和表现虽然受到年龄和体重过度的相似影响，但受到不同的代谢因素影响。
