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慢性疲劳综合征:理解一种复杂的疾病。

Chronic fatigue syndrome: understanding a complex illness.

机构信息

University of Southampton, Infection, Inflammation and Immunity Division, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.

出版信息

Nat Rev Neurosci. 2011 Jul 27;12(9):539-44. doi: 10.1038/nrn3087.

DOI:10.1038/nrn3087
PMID:21792218
Abstract

Chronic fatigue syndrome (CFS) is a debilitating illness that affects many people. It has been marred by controversy, from initial scepticism in the medical community about the existence of the condition itself to continuing disagreements--mainly between some patient advocacy groups on one side, and researchers and physicians on the other--about the name for the illness, its aetiology, its pathophysiology and the effectiveness of the few currently available treatments. The role of the CNS in the disease is central in many of these discussions. Nature Reviews Neuroscience asked four scientists involved in CFS research about their views on the condition, its causes and the future of research aimed at improving our understanding of this chronic illness.

摘要

慢性疲劳综合征(CFS)是一种使人虚弱的疾病,影响了许多人。它一直备受争议,从医学界最初对这种疾病本身的存在持怀疑态度,到目前为止,一直存在着持续的分歧——主要是一些患者权益团体一方,以及研究人员和医生另一方,他们对疾病的名称、病因、病理生理学以及目前为数不多的有效治疗方法存在分歧。中枢神经系统(CNS)在这些讨论中起着核心作用。《自然评论神经科学》采访了四位参与 CFS 研究的科学家,询问他们对这种慢性疾病的看法、病因以及未来旨在增进我们对这种慢性疾病的理解的研究。

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Chronic fatigue syndrome: a diagnostic challenge for the laboratory.慢性疲劳综合征:实验室面临的诊断挑战。
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Longitudinal cytokine and multi-modal health data of an extremely severe ME/CFS patient with HSD reveals insights into immunopathology, and disease severity.一名患有高度敏感性疾病(HSD)的极其严重的肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)患者的纵向细胞因子和多模态健康数据揭示了免疫病理学和疾病严重程度的相关见解。
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本文引用的文献

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Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial.适应性起搏疗法、认知行为疗法、分级运动疗法和慢性疲劳综合征专科医疗的比较(PACE):一项随机试验。
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Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome.在慢性疲劳综合征患者血细胞中检测到一种传染性逆转录病毒,XMRV。
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Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives.
推进研究与治疗:肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)临床试验概述及未来展望
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Focus on post-exertional malaise when approaching ME/CFS in specialist healthcare improves satisfaction and reduces deterioration.在专科医疗中诊治肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)时关注运动后不适,可提高满意度并减少病情恶化。
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Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome.针刺治疗慢性疲劳综合征的中枢机制研究进展
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Multi-'omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients.肠微生物组-宿主相互作用的多组学研究:在短期和长期肌痛性脑脊髓炎/慢性疲劳综合征患者中的研究。
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Bright, but allergic and neurotic? A critical investigation of the "overexcitable genius" hypothesis.聪明,但过敏又神经质?对“过度兴奋的天才”假说的批判性调查。
Front Psychol. 2022 Dec 23;13:1051910. doi: 10.3389/fpsyg.2022.1051910. eCollection 2022.
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Tai Chi increases functional connectivity and decreases chronic fatigue syndrome: A pilot intervention study with machine learning and fMRI analysis.太极拳可增加功能连接并减轻慢性疲劳综合征:一项基于机器学习和 fMRI 分析的初步干预研究。
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