钯催化羧酸与甲苯的苄基化反应：通过苄位 C-H 活化。
Palladium-catalyzed benzylation of carboxylic acids with toluene via benzylic C-H activation.
机构信息
Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China.
出版信息
Org Lett. 2013 Aug 16;15(16):4098-101. doi: 10.1021/ol401687f. Epub 2013 Jul 29.
PMID:23889331
Abstract
Direct benzylation of carboxylic acids with toluene has been developed via palladium-catalyzed C-H acyloxylation under 1 atm of oxygen. This reaction demonstrates good functional group tolerance and high yields, providing a facile, atom-economic, and efficient method for the synthesis of benzyl esters.
摘要
通过钯催化的 C-H 酰氧基化反应，在 1 个大气压的氧气下，实现了羧酸与甲苯的直接苄基化。该反应具有良好的官能团耐受性和高产率，为合成苄酯提供了一种简便、原子经济性和高效的方法。
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