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牙种植体失败中的糖基化和氧化应激：病例系列

Glycation and oxidative stress in the failure of dental implants: a case series.

作者信息

Pietropaoli Davide, Ortu Eleonora, Severino Marco, Ciarrocchi Irma, Gatto Roberto, Monaco Annalisa

出版信息

BMC Res Notes. 2013 Jul 26;6:296. doi: 10.1186/1756-0500-6-296.

DOI:10.1186/1756-0500-6-296
PMID:23890159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3733866/
Abstract

BACKGROUND

The aim of this case series/control study is to investigate the presence of the Advanced Glycation End products (AGEs) and oxidative stress in periimplantitis.

FINDINGS

The Western Blotting analysis on periimplantitis and periodontal disease tissues showed marked increase of AGEs when compared to healthy control tissues. Also TBARS assay of whole saliva confirmed the expectations, showing higher oxidative stress levels in periimplantitis and periodontitis groups than in healthy group.

CONCLUSIONS

With the limitation of the sample size, these results showed that oxidative stress could be involved in the aetiology of periimplantitis. This hypothesis could lead to new therapeutic strategies in periimplantitis, using antioxidant approach in addition to conventional treatments.

摘要

背景

本病例系列/对照研究的目的是调查种植体周围炎中晚期糖基化终末产物（AGEs）的存在情况及氧化应激。

研究结果

对种植体周围炎和牙周病组织进行的蛋白质印迹分析显示，与健康对照组织相比，AGEs显著增加。全唾液的硫代巴比妥酸反应物（TBARS）检测也证实了预期结果，表明种植体周围炎和牙周炎组的氧化应激水平高于健康组。

结论

由于样本量的限制，这些结果表明氧化应激可能参与种植体周围炎的病因。这一假说可能会带来种植体周围炎的新治疗策略，即在传统治疗的基础上采用抗氧化方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9199/3733866/37ac34b2f338/1756-0500-6-296-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9199/3733866/b501789daec2/1756-0500-6-296-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9199/3733866/37ac34b2f338/1756-0500-6-296-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9199/3733866/b501789daec2/1756-0500-6-296-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9199/3733866/37ac34b2f338/1756-0500-6-296-2.jpg

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