Academic Medical Center University of Amsterdam (AMC), Department of Psychiatry, Meibergdreef 5, 1105 AZ Amsterdam, The Netherlands.
Psychiatry Res. 2013 Dec 15;210(2):491-7. doi: 10.1016/j.psychres.2013.06.040. Epub 2013 Jul 24.
Earlier studies indicated that personality characteristics contribute to symptomatic outcome in patients with psychotic disorders. The aim of the present study was to further explore this connection by examining the relationship between the Five-Factor Model (FFM) personality traits and a dimensional liability for psychosis. FFM traits according to the NEO-FFI and levels of subclinical psychotic symptoms according to the CAPE were assessed in 217 patients with psychotic disorders, 281 of their siblings and 176 healthy controls. Psychotic symptoms according to the PANSS were assessed in the patient group. Patients differed from siblings and controls on four of the five FFM traits, all but Openness. Siblings reported higher levels of Neuroticism than controls, but lower levels than patients. Particularly lower Agreeableness, and to a lesser degree, higher Neuroticism and lower Extraversion were associated with more severe symptoms in patients. Furthermore, higher Neuroticism and higher Openness were associated with higher levels of subclinical psychotic experiences in all three groups. Associations were strongest in patients. Our findings suggest that levels of Neuroticism increase with the level of familial risk for psychosis. Levels of Openness may reflect levels of impairment that distinguish clinical from subclinical symptomatology.
早期研究表明，人格特征与精神病患者的症状结果有关。本研究旨在通过研究五因素模型（FFM）人格特质与精神病的维度易感性之间的关系来进一步探讨这一联系。使用 NEO-FFI 评估了 217 名精神病患者、281 名患者的兄弟姐妹和 176 名健康对照者的 FFM 特质，使用 CAPE 评估了亚临床精神病症状的水平。使用 PANSS 评估了患者组的精神病症状。患者在五个 FFM 特质中的四个特质上与兄弟姐妹和对照组不同，除了开放性。兄弟姐妹的神经质水平高于对照组，但低于患者。在患者中，特别低的宜人性，以及在较小程度上，较高的神经质和较低的外向性与更严重的症状有关。此外，神经质和开放性较高与所有三组的亚临床精神病体验水平较高有关。在患者中关联最强。我们的研究结果表明，神经质水平随精神病的家族风险水平而增加。开放性水平可能反映了区分临床和亚临床症状学的损伤水平。
