Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, SE-106 91, Stockholm, Sweden.
Nat Rev Microbiol. 2013 Sep;11(9):627-38. doi: 10.1038/nrmicro3077. Epub 2013 Jul 29.
Growth and proliferation of all cell types require intricate regulation and coordination of chromosome replication, genome segregation, cell division and the systems that determine cell shape. Recent findings have provided insight into the cell cycle of archaea, including the multiple-origin mode of DNA replication, the initial characterization of a genome segregation machinery and the discovery of a novel cell division system. The first archaeal cytoskeletal protein, crenactin, was also recently described and shown to function in cell shape determination. Here, we outline the current understanding of the archaeal cell cycle and cytoskeleton, with an emphasis on species in the genus Sulfolobus, and consider the major outstanding questions in the field.
所有细胞类型的生长和增殖都需要精细调节和协调染色体复制、基因组分离、细胞分裂以及决定细胞形状的系统。最近的研究结果提供了对古菌细胞周期的深入了解，包括 DNA 复制的多起点模式、基因组分离机制的初步特征以及新型细胞分裂系统的发现。最近还描述了第一种古菌细胞骨架蛋白 crenactin，并证明其在细胞形状确定中起作用。在这里，我们概述了古菌细胞周期和细胞骨架的当前理解，重点介绍 Sulfolobus 属中的物种，并考虑该领域的主要未解决问题。
