Yazdi Britta, Riefler Peter, Fischmüller Kristina, Sonek Jiri, Hoopmann Markus, Kagan Karl Oliver
Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany.
Prenat Diagn. 2013 Dec;33(12):1124-30. doi: 10.1002/pd.4205. Epub 2013 Sep 9.
The aim of this study is to evaluate whether the measurement of the frontal space (FS) improves first trimester combined aneuploidy screening.
We have presented a retrospective study including 2D images of the nuchal translucency measurement of 300 euploid and 133 trisomic fetuses that were seen at the prenatal department at the University of Tuebingen, Germany. For the FS measurement, a mandibulo-maxillary line (MML) was created by connecting the anterior edge of the mental protuberance and anterior edge of the maxilla. The MML was then extended upwards. A measurement was taken perpendicular from the MML to the skin line over the point of largest excursion of the fetal forehead. After transformation into z-scores based on the crown rump length, the FS distribution in fetuses with trisomy 21, 18, and 13 was compared with the euploid group by using a student's t-test.
The mean FS in euploid fetuses was 1.25 mm. In fetuses with trisomy 21, 18, and 13, the mean FS measurements were 2.96, 3.22, and 2.03 mm. In euploid and trisomy 21, 18, and 13 pregnancies, FS measurements were above the 95th centile in 5.3%, 41.1%, 34.3%, and 12.5% of the cases. The mean z-scores were significantly higher in trisomy 21 and 18.
First trimester FS measurement may improve first trimester combined screening.
本研究旨在评估测量额部空间（FS）是否能改善孕早期联合非整倍体筛查。
我们开展了一项回顾性研究，纳入了德国图宾根大学产前科室300例整倍体胎儿和133例三体胎儿的颈部半透明测量的二维图像。对于FS测量，通过连接颏隆突前缘和上颌骨前缘创建下颌 - 上颌线（MML）。然后将MML向上延伸。在胎儿前额最大偏移点处，从MML垂直向皮肤线进行测量。基于顶臀长转换为z分数后，使用学生t检验将21、18和13三体胎儿的FS分布与整倍体组进行比较。
整倍体胎儿的平均FS为1.25毫米。21、18和13三体胎儿的平均FS测量值分别为2.96、3.22和2.03毫米。在整倍体以及21、18和13三体妊娠中，FS测量值高于第95百分位数的病例分别占5.3%、41.1%、34.3%和12.5%。21和18三体的平均z分数显著更高。
孕早期FS测量可能会改善孕早期联合筛查。
